BALF – Communicable Diseases Research

Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway

Article

Published on 2023-01-302022-11-16
Journal: Journal of ethnopharmacology
[Category] 신종인플루엔자, 치료기술,

Low BALF CD4 T cells count is associated with extubation failure and mortality in critically ill covid-19 pneumonia

낮은 BALF CD4 T 세포 수는 중환자의 covid-19 폐렴에서 발관 실패 및 사망률과 관련이 있습니다

Article

Published on 2022-12-012022-09-11
Journal: Annals of Medicine
[Category] 바이오마커, 진단,

[키워드] affected alveolar alveolar macrophage analysed average BALF BALF CD4 T-cells count baseline Biomarker bivariate analysis Bronchoalveolar lavage fluid caspase caspase-3 cause CD4 CD4 T cell CD4 T-cell Characteristics clinical Clinical characteristics conducted COVID-19 COVID-19 patients COVID-19 pneumonia COVID-19 pneumonia patient COVID-19 pneumonia patients Critically ill critically ill COVID-19 patients Critically ill COVID-19 pneumonia D-dimer D-dimer level eight enrolled extubation failure. groups help IL-17 IL-6 immunopathology IMPROVE Indonesia intubation Invasive mechanical ventilation Laboratory lung Macrophage material Mortality no significant difference no significant differences outcome Patient performed Pneumonia profile Referral reported right lung severe pneumonia severity significant differences significantly survived T-cells Tertiary Tregs understanding was performed were measured
[DOI] 10.1080/07853890.2022.2095012 PMC 바로가기 [Article Type] Article

Atypical pneumonia caused by Chlamydia psittaci during the COVID-19 pandemic

Research article

Published on 2022-09-012022-10-05
Journal: International Journal of Infectious Diseases
[Category] 진단, 치료기술,

NMR spectroscopy spotlighting immunogenicity induced by COVID-19 vaccination to mitigate future health concerns

Review article

Published on 2022-08-222022-10-05
Journal: Current Research in Immunology
[Category] 바이오마커, 유전자 메커니즘,

SARS-CoV-2-positive patients display considerable differences in proteome diversity in urine, nasopharyngeal, gargle solution and bronchoalveolar lavage fluid samples

SARS-CoV-2-양성 환자는 소변, 비인두, 양치액 및 기관지폐포 세척액 샘플에서 단백질체 다양성에 상당한 차이를 나타냅니다.

Article

Published on 2022-08-082022-09-11
Journal: PLoS ONE
[Category] SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 BALF Beijing Bronchoalveolar lavage fluid center chance change characterized Charle China collected coronavirus coronavirus 2 database demonstrated Department downloaded followed by gargle gargle solution Germany Human human body in urine individual infected with SARS-CoV-2 Infection information investigated Mayo Clinic Medicine nasopharyngeal nasopharyngeal sample Nasopharyngeal samples pathology peptide Protein Proteins proteome proteomic proteomics respiratory SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 proteome SARS-CoV-2 virus SARS-CoV-2 viruses SARS-CoV-2-positive patient SARS-CoV-2-positive patients Science secreted seropositive individuals Severe acute respiratory syndrome significantly more solution status technology the SARS-CoV-2 virus UniProt unique university Urine USA virus viruses was used while
[DOI] 10.1371/journal.pone.0271870 PMC 바로가기 [Article Type] Article

Metagenomic Next-Generation Sequencing Reveals the Profile of Viral Infections in Kidney Transplant Recipients During the COVID-19 Pandemic

Metagenomic 차세대 시퀀싱은 COVID-19 팬데믹 기간 동안 신장 이식 수혜자의 바이러스 감염 프로필을 보여줍니다

Article

Published on 2022-07-112022-09-11
Journal: Frontiers in Public Health
[Category] 치료기술,

[키워드] Analysis BALF Biomarker Blood Blood samples Bronchoalveolar lavage fluid CMV compared and analyzed COVID-19 COVID-19 pandemic cytomegalovirus database detection rate dominant higher risk IMPROVE indicated Infection JC polyomavirus kidney kidney transplant recipient kidney transplant recipients Kidney transplantation metagenomic Metagenomic next-generation sequencing Next-generation sequencing nucleic acid nucleic acids profile recipient rejection reveal sequence simian virus torque teno virus Transplant Urine viral infection viral infections viral nucleic acid viral nucleic acids virus virus virus infection virus. viruses
[DOI] 10.3389/fpubh.2022.888064 PMC 바로가기 [Article Type] Article

Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum

폴리(I:C) 플러스 명반과 관련된 SARS-CoV-2 삼량체 스파이크 단백질의 면역원성

Article

Published on 2022-06-302022-09-12
Journal: Frontiers in Immunology
[Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] addition adjuvant adjuvants alum antibody B cell BALF Bronchoalveolar lavage fluid CD4 CD8 Cellular immune response Combination domain ELISA enzyme evaluated expected germinal centers IgA IgG IgG anti-spike antibody IgG1 IgG2a immunization immunogenicity immunosorbent in vitro inactivated induce intradermal route lung Lung inflammation mice Neutralization assay Neutralizing titer neutralizing titers neutrophil recruitment New Poly (I:C) poly(I:C positive prefusion produced producing Protein RBD reduced reduction in required SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 virus serum spike Spike protein Subtypes supported T cell Th1 Th1 phenotype the SARS-CoV-2 trimeric vaccination Vaccination strategy Vaccine vaccine.
[DOI] 10.3389/fimmu.2022.884760 PMC 바로가기 [Article Type] Article

Identification of bronchoalveolar and blood immune-inflammatory biomarker signature associated with poor 28-day outcome in critically ill COVID-19 patients

중환자 COVID-19 환자에서 좋지 않은 28일 결과와 관련된 기관지 폐포 및 혈액 면역 염증 바이오마커 식별

Article

Published on 2022-06-092022-09-11
Journal: Scientific Reports
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission assays BAL BAL fluid BALF Biological biological profile biomarker signature Blood blood concentration bronchoalveolar Bronchoalveolar lavage Characteristics clinical Clinical outcome Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine defined described eicosanoid Eicosanoids elicited ELISA endothelial injury exhibited fiberoptic bronchoscopy Health Organization identification IFN-γ IL-10 IL-22 IL-5 IL-6 Infection Inflammatory response intensive care intensive care unit interferon Local metabolomic analysis neutrophil outcome Patient performed phenotype respiratory SARS-CoV-2 scale severe acute respiratory syndrome Coronavirus type I interferon Vascular Vasoactive VEGF WHO-CPS World Health Organization
[DOI] 10.1038/s41598-022-13179-0 PMC 바로가기 [Article Type] Article

Reduced DMPC and PMPC in lung surfactant promote SARS-CoV-2 infection in obesity

폐 계면활성제의 감소된 DMPC 및 PMPC는 비만에서 SARS-CoV-2 감염을 촉진합니다

Article

Published on 2022-06-012022-09-11
Journal: Metabolism: clinical and experimental
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 ACE2 expression ACE2 receptor Analysis BALF bind Bronchoalveolar lavage fluid cell-cell fusion assay characterized cholesterol COVID-19 COVID-19 disease COVID-19 pneumonia D614G mutant SARS-CoV-2 Defense DMPC Effect effector cells elevated expressing fat Feeding HEK293T HEK293T cell HEK293T cells High fat diet Hospitalization increased risk Increasing Infection infections inhibited inhibitory effect Inhibitory effects Lipid lipid composition lipid metabolism lipids lung lung surfactant lung tissue Lungs mechanism metabolism mice myristic acid obese obesity outcomes overexpression Phosphatidylcholine Pneumocytes produced promote Protein reduced respiratory virus reversed risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus infection SARS-CoV-2 viral loads SARS-CoV-2. severe COVID-19 disease Severe COVID-19 pneumonia Spike protein surfactant the Spike Triglyceride triglycerides trimyristin Type II pneumocyte type II pneumocytes Vero-E6 cell Vero-E6 cells was performed were used wild type
[DOI] 10.1016/j.metabol.2022.155181 PMC 바로가기 [Article Type] Article

Pharmacokinetics and safety of inhaled ivermectin in mice as a potential COVID-19 treatment

잠재적인 COVID-19 치료제로서 생쥐에서 흡입된 이버멕틴의 약동학 및 안전성

Article

Published on 2022-05-102022-09-11
Journal: International journal of pharmaceutics
[Category] COVID19(2023년), SARS, 치료법, 치료제,

[키워드] administration analyzed Antiviral antiviral efficacy BALB/c mice BALF binding Bronchoalveolar lavage fluid clinically collected Concentration concentrations COVID-19 Critical drug Dry Dry powder aerosol Formulation healthy histological in vitro in vitro experiment Inhalable ivermectin inhalation Inhaled intratracheal administration investigated Ivermectin kidney Lactose less limit limitation liver Local low dose lung Lungs mice Mild overcome pharmacokinetic pharmacokinetics plasma Protein Protein binding resolved respiratory tract Safety SARS-CoV-2 spleen spray Spray drying. therapeutic Toxicity Treatment viral pathology was used
[DOI] 10.1016/j.ijpharm.2022.121688 PMC 바로가기 [Article Type] Article